Intramolecular Borrowing Hydrogen Catalysis for Common Alkaloid Cores
Over the 2021 summer I began and headed a project that aimed to develop common alkaloid core nitrogen bicycles by applying Borrowing Hydrogen Catalysis (BHC) to effect ring closure. Traditional BHC is performed intermolecularly, while this project investigates its intramolecular capabilities, which comes with unique chemical nuances. The project also aims to develop new iron and cobalt catalysts, since BHC is often accomplished using catalysts that contain rare earth metals such as iridium, rhodium, and rhenium. The project is ongoing with an aim to be completed before my 2022 graduation.
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Selective Oxidation to Disulfides with Oxoammonium Salts
Throughout my time in the Lambert group (2021-ongoing) I've also done much work on a project which aims to generate disulfides using Bobbitt's Salt (4-acetamidoTEMPO). The exact method of oxidation, especially for the electrochemical reaction, has posed unique questions and challenges in our pursuit of elucidating the exact mechanism due to an unprecedented observed selectivity. The project is soon to be finished, with plans to submit the manuscript early December.
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Chemical Competency for Plasmid-based Genetic Engineering
As a part of the Math and Science Highschool Academy I attended, In 2019-2020 I completed a senior research project investigating the induction of chemical competency in bacteria for genetic engineering. The project's primary focus was to further the understanding of how particular ionic species aid in the genetic transformation process by varying the specific salts utilized. Though the project was rather limited by funding, my results indicated potential differences in effectiveness of transformation between Magnesium Chloride and Strontium Chloride. In the future I may reinvestigate this If I happen to be better funded.
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